Professor, Showa Medical University School of Medicine
EDUCATIONS / TRAINING
B.Sc. (1990)
Tokyo Institute of Technology, Biological Science, Tokyo, Japan
Ph.D. (1995)
Tokyo Institute of Technology, Biological Science, Tokyo, Japan
EXPERIENCES
1995-1998
JSPS Research Fellow, University of Tokyo, Tokyo, Japan
1997-1999
Research Fellow, University of Michigan, Ann Arbor, MI, USA
2000-2006
Research Investigator, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
2006-2016
Laboratory Chief, National Institute of Infectious Diseases, Tokyo, Japan
2016-2024
Associate Professor, Kobe University Graduate School of Medicine, Kobe, Japan
2024
present Professor, Showa Medical University School of Medicine, Tokyo, Japan
PUBLICATIONS
1. Maehama T, et al. Molecular mechanisms and related human diseases. Cancer Sci 114: 2078-2086, 2023
2. Soyama H, et al. Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl. Acad Sci USA 119: e2123134119, 2022
3. Maehama T, et al. The role of Hippo-YAP signaling in squamous cell carcinomas. Cancer Sci 112: 51-60, 2021
4. Omori H, et al. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv 6: eaay3324, 2020
5. Sasaki M, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med 17: 944-951, 2011
6. Okahara F, et al. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J Biol Chem 279: 45300-45303, 2004
7. Maehama T, et al. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 70: 247-279, 2001
8. Lee JO, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323-334, 1999
9. Maehama T, et al. A tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9: 125-128, 1999
10. Maehama T, et al. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378, 1998
RESEARCH FOCUS
Our group has focused on the molecular mechanism for the development and progression of cancers caused by disruption of three tumor suppressor pathways: p53, PTEN, and the Hippo pathway. PTEN is one of the most frequently aberrant tumor suppressor gene, and is primarily responsible for the negative regulation of cell proliferation signals. We recently have succeeded in identifying several new PTEN regulatory molecules, as a result of our genome-wide screening, and are in the process of elucidating their mechanisms of action. We will continue our research focusing on the relationship between these regulatory molecules and cancer to elucidate the loss of function of PTEN and cancer regulation by new molecular mechanisms.
